The Drosophila salivary gland has emerged as an outstanding model system for the process of organ formation. Many of the component steps, from initial regional specification through cell specialization and morphogenesis, are known and many of the genes required for these different processes have been identified. The salivary gland is a relatively simple organ; the entire gland comprises of only two major cell types, which derive from a single contiguous primordium. Salivary cells cease dividing once they are specified, and organ (...) growth is achieved simply by an increase in size of individual cells, thus eliminating concerns about the potential unequal distribution of determinants during mitosis. Drosophila salivary glands form by the same cellular mechanisms as organs in higher organisms, including regulated cell shape changes, cell intercalation and directed cell migration. Thus, learning how these events are coordinated for tissue morphogenesis in an organism for which the genetic and molecular tools are unsurpassed should provide excellent paradigms for dissecting related processes in the more intricate organs of more complicated species. BioEssays 23:901–911, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

ABSTRACTHIV/AIDS harms the viability and competitiveness of African businesses. As a consequence, companies increasingly subscribe to the view that taking a proactive role to combat HIV/AIDS is not simply a question of compassion and good corporate citizenship. Rather, these firms see assertive action against HIV as critical to their long‐term profitability, and some have concluded that it is cost effective even in the short term. The article discusses how South African companies are taking action against HIV in ways that set (...) new benchmarks, enhance the effectiveness of international AIDS advocacy efforts, and spur businesses across Africa and beyond to strengthen their corporate responses to HIV/AIDS. (shrink)

Recent experiments have been used to “edit” genomes of various plant, animal and other species, including humans, with unprecedented precision. Furthermore, editing the Cas9 endonuclease gene with a gene encoding the desired guide RNA into an organism, adjacent to an altered gene, could create a “gene drive” that could spread a trait through an entire population of organisms. These experiments represent advances along a spectrum of technological abilities that genetic engineers have been working on since the advent of recombinant DNA (...) techniques. The scientific and bioethics communities have built substantial literatures about the ethical and policy implications of genetic engineering, especially in the age of bioterrorism. However, recent CRISPr/Cas experiments have triggered a rehashing of previous policy discussions, suggesting that the scientific community requires guidance on how to think about social responsibility. We propose a framework to enable analysis of social responsibility, using two example.. (shrink)

The US National Institute of Health’s Human Microbiome Project aims to use genomic techniques to understand the microbial communities that live on the human body. The emergent field of microbiome science brought together diverse disciplinary perspectives and technologies, thus facilitating the negotiation of differing values. Here, we describe how values are conceptualized and negotiated within microbiome research. Analyzing discussions from a series of interdisciplinary workshops conducted with microbiome researchers, we argue that negotiations of epistemic, social, and institutional values were inextricable (...) from the reflective and strategic category work that defined and organized the microbiome as an object of study and a potential future site of biomedical intervention. Negotiating the divergence or tension between emerging scientific and regulatory classifications also activated “values levers” and opened up reflective discussions of how classifications embody values and how these values might differ across domains. These data suggest that scholars at the intersections of science and technology studies, ethics, and policy could leverage such openings to identify and intervene in the ways that ethical/regulatory and scientific/technical practices are coproduced within unfolding research. (shrink)

Concerns regarding corporate ethics have grown steadily throughout the past decade. In order to remain competitive, many organizational leaders are faced with the challenge of creating an ethical environment within their organization. A model is presented showing the process and elements necessary for the institutionalization of organizational ethics. The transformational leadership style lends itself well to the creation of an ethical environment and is suggested as a means to facilitate the institutionalization of corporate ethics. Finally, the benefits of using transformational (...) leadership are demonstrated through the components of a psychological contract, organizational commitment, and ethical culture to institutionalize organizational ethics. (shrink)

Past research has demonstrated that employees’ perceptions of abusive supervision are positively associated with the enactment of bullying behaviors. However, an investigation of the factors influencing employees’ decision to bully others at work has yet to be completed. In this study, we propose that the relationship between perceptions of abusive supervision and the enactment of bullying behaviors is mediated by state self-regulation, and that active coping moderates the relationship between state self-regulation and bullying. Further, we analyze how the situational context (...) affects employees’ levels of self-regulatory resource depletion and ultimately, the extent to which they engage in bullying behaviors. A moderated mediation analysis using time-separated data provided support for our hypotheses, suggesting that employees’ state self-regulation helps explain why abusive supervision is associated with bullying and that active coping helps to reduce bullying behaviors. Further, the results suggest that negative environments are associated with more bullying. Contributions, practical implications, and future research directions are discussed. (shrink)

Many patients experience aspects of treatment and care as dehumanizing because the body is considered separate from the self and its life context. An attempt to transcend viewing persons in dualistic terms is posed by phenomenologists who focus not on “the body” as such but on what it means to be “embodied.” In this paper, we review the relevance of the phenomenology of the body for health care and report the results of comparing Sally Gadow’s phenomenological insights about body-self unity (...) with a qualitative analysis of patients’ accounts of satisfaction with the outcome of hand surgery. We illustrate the ways in which our findings were and were not congruent with Gadow’s conceptualization of embodiment and highlight aspects that are ambiguous. We conclude that the body-self dialectical relationship should be recast as a body-self-society trialectic and discuss the implications of this new conceptualization for clinical practices. (shrink)

This cross-sectional study of three generations of healthcare executives examines whether age cohort is the key determiner of ethical values. Responses to a national survey using the Rokeach Value Survey indicate that, contrary to widely reported beliefs that suggest otherwise, the age cohort groups in this sample exhibit virtually identical value preferences. The concept of career attraction is introduced to explain the similarities in value preference, and it is further suggested that generational differences may be nullified by the homogeneous demands (...) of organizational life in a healthcare setting. Implications for ethical decisionmaking are discussed.Does age cohort affiliation influence healthcare executive values and consequent ethical judgements? The greater body of literature clearly suggests the answer is yes, yet an empirical assessment of the question has never before been reported. The attention given this issue to date has been focused on the generational differences between the three age cohorts in the workplace today: Matures, Boomers, and Generation Xers (1). Defined as a group of people who share a given historical or socially structured life experience, an age cohort is believed to have a relatively stable influence over the decisionmaking of individuals, and serves to distinguish one generation from another (2)(3)(4). Generation X, or GenXers as they are commonly referred to, are comprised of individuals born between 1961 and 1981. Baby Boomers, or Boomers as they are popularly known, are those born between 1943 and 1960. Matures is the name given to characterize the group of people born between born 1925 and 1942. [Birth dates defining generational cohorts vary slightly among multiple sources. The dates used in this study are from Strauss and Howe (1991), though the nomenclature is not.]. (shrink)

Background Machine learning (ML) is utilized increasingly in health care, and can pose harms to patients, clinicians, health systems, and the public. In response, regulators have proposed an approach that would shift more responsibility to ML developers for mitigating potential harms. To be effective, this approach requires ML developers to recognize, accept, and act on responsibility for mitigating harms. However, little is known regarding the perspectives of developers themselves regarding their obligations to mitigate harms.Methods We conducted 40 semi-structured interviews with (...) developers of ML predictive analytics applications for health care in the United States.Results Participants varied widely in their perspectives on personal responsibility and included examples of both moral engagement and disengagement, albeit in a variety of forms. While most (70%) of participants made a statement indicative of moral engagement, most of these statements reflected an awareness of moral issues, while only a subset of these included additional elements of engagement such as recognizing responsibility, alignment with personal values, addressing conflicts of interests, and opportunities for action. Further, we identified eight distinct categories of moral disengagement reflecting efforts to minimize potential harms or deflect personal responsibility for preventing or mitigating harms.Conclusions These findings suggest possible facilitators and barriers to the development of ethical ML that could act by encouraging moral engagement or discouraging moral disengagement. Regulatory approaches that depend on the ability of ML developers to recognize, accept, and act on responsibility for mitigating harms might have limited success without education and guidance for ML developers about the extent of their responsibilities and how to implement them. (shrink)

Business ethics educators strive to produce graduates who not only grasp the principles of ethical decision-making, but who can apply that business ethics education when faced with real-world challenges. However, this has proven especially difficult, as good intentions do not always translate into ethical awareness and action. Complementing a behavioral ethics approach with insights from social psychology, we developed an interventional class module with both online and in-class elements aimed at increasing students’ awareness of their own susceptibility to unconscious biases (...) and, consequently, unethical behaviors. We deployed this intervention within a problem-based learning course, in which students completed real-world projects for actual business clients. Our results suggest that although students appeared universally aware of the importance of ethical issues in business and generally espoused intentions to act ethically, those who received the intervention were significantly more likely to recognize their own susceptibility to perpetuating unethical business behavior and to identify ethical issues specific to their real-world projects. These results have important implications for behavioral ethics pedagogy and provide a de-biasing interventional approach for bridging classroom knowledge with real-world skills. (shrink)

Archaeology and History of Eighth-Century Judah. Edited by Zev I. Farber and Jacob l. Wright. Ancient Near East Monographs, vol. 23. Atlanta: SBL Press, 2018. Pp. xv + 593, illus. $79.95.

We investigate the dynamics of sensory integration for perceiving musical performance, a complex natural behavior. Thirty musically trained participants saw, heard, or both saw and heard, performances by two clarinetists. All participants used a sliding potentiometer to make continuous judgments of tension (a measure correlated with emotional response) and continuous judgments of phrasing (a measure correlated with perceived musical structure) as performances were presented. The data analysis sought to reveal relations between the sensory modalities (vision and audition) and to quantify (...) the effect of seeing the performances on participants' overall subjective experience of the music. In addition to traditional statistics, functional data analysis techniques were employed to analyze time-varying aspects of the data. The auditory and visual channels were found to convey similar experiences of phrasing but different experiences of tension through much of the performances. We found that visual information served both to augment and to reduce the experience of tension at different points in the musical piece (as revealed by functional linear modeling and functional significance testing). In addition, the musicians' movements served to extend the sense of phrasing, to cue the beginning of new phrases, to indicate musical interpretation, and to anticipate changes in emotional content. Evidence for an interaction effect suggests that there may exist an emergent quality when musical performances are both seen and heard. The investigation augments knowledge of human communicative processes spanning language and music, and involving multiple modalities of emotion and information transfer. (shrink)

How did the Bhagavadgãtà first become an object of German philosophical and philological inquiry? How were its foundational concepts initially interpreted within German intellectual circles, and what does this episode in the history of cross-cultural encounter teach us about the status of comparative philosophy today? This book addresses these questions through a careful study of the figures who read, translated and interpreted the Bhagavadgãtà around the turn of the nineteenth century in Germany: J.G. Herder, F. Majer, F. Schlegel, A.W. Schlegel, (...) W. von Humboldt, and G.W.F. Hegel. Methodologically, the study attends to the intellectual contexts and prejudices that framed the early reception of the text. But it also delves deeper by investigating the way these frameworks inflected the construction of the Bhagavadgãtà and its foundational concepts through the scholarly acts of excerpting, anthologization, and translation. Overall, the project contributes to the pluralization of Western philosophy and its history while simultaneously arguing for a continued critical alertness in cross-cultural comparison of philosophical and religious worldviews. (shrink)

Conscientious objections (CO) can be disruptive in a variety of ways and may disadvantage patients and colleagues who must step-in to assume care. Nevertheless, nurses have a right and responsibility to object to participation in interventions that would seriously harm their sense of integrity. This is an ethical problem of balancing risks and responsibilities related to patient care. Here we explore the problem and propose a nonlinear framework for exploring the authenticity of a claim of CO from the perspective of (...) the nurse and of those who must evaluate such claims. We synthesized the framework using Rest’s Four Component Model of moral reasoning along with tenets of the International Council of Nursing’s (ICN) Code of Ethics for Nurses and insights from relevant ethics and nursing ethics literature. The resulting framework facilitates evaluating potential consequences of a given CO for all involved. We propose that the framework can also serve as an aid for nurse educators as they prepare students for practice. Gaining clarity about the sense in which the concept of conscience provides a defensible foundation for objecting to legally, or otherwise ethically, permissible actions, in any given case is critical to arriving at an ethical and reasonable plan of action. (shrink)

How did the Bhagavadgãtà first become an object of German philosophical and philological inquiry? How were its foundational concepts initially interpreted within German intellectual circles, and what does this episode in the history of cross-cultural encounter teach us about the status of comparative philosophy today? This book addresses these questions through a careful study of the figures who read, translated and interpreted the Bhagavadgãtà around the turn of the nineteenth century in Germany: J.G. Herder, F. Majer, F. Schlegel, A.W. Schlegel, (...) W. von Humboldt, and G.W.F. Hegel. Methodologically, the study attends to the intellectual contexts and prejudices that framed the early reception of the text. But it also delves deeper by investigating the way these frameworks inflected the construction of the Bhagavadgãtà and its foundational concepts through the scholarly acts of excerpting, anthologization, and translation. Overall, the project contributes to the pluralization of Western philosophy and its history while simultaneously arguing for a continued critical alertness in cross-cultural comparison of philosophical and religious worldviews. (shrink)

This dissertation investigates the initial reception of the Bhagavad Gita in German intellectual circles, focusing in particular on the ways that the German Romantics who translated and anthologized the text constituted it as an object of European knowledge. By examining the intellectual debates and textual practices at play in early nineteenth century representations of Indian religious culture, this project contributes to the contemporary debate about Orientalism, which often lacks focus because of inattention to historical context. In addition, by bringing this (...) under-investigated topic to light, the dissertation adds an important chapter to the history of the study of religion and offers historical perspective on the comparative philosophy of religion. ;The works of Johann Gottfried Herder, Friedrich Schlegel, August Wilhelm Schlegel, Wilhelm von Humboldt, and G. W. F. Hegel provide the matrix of this project. With these writings a German discourse on India took shape. Local intellectual preoccupations guided the Romantic presentation of the Gita, permeated its translations, and were thus enlisted to accommodate its difference. These preoccupations were thematized first in Herder's experimentations and then gained clarity in the work of the Schlegel brothers. Later exchanges between von Humboldt and Hegel illustrate the way that these preoccupations were reinterpreted after early Romantic enthusiasm had dissipated and conventions of academic discipline had evolved. ;The dissertation concludes by asserting that Romanticism leaves a legacy wherein broad cultural "myths" can dominate the "logos" of scholarship on India and Hindu religious sources. Reflection on the history of cross-cultural inquiry draws attention to such "myths" and thus enhances the self-consciousness of future scholarship. (shrink)

How did the _Bhagavadgãtà_ first become an object of German philosophical and philological inquiry? How were its foundational concepts initially interpreted within German intellectual circles, and what does this episode in the history of cross-cultural encounter teach us about the status of comparative philosophy today? This book addresses these questions through a careful study of the figures who read, translated and interpreted the _Bhagavadgãtà_ around the turn of the nineteenth century in Germany: J.G. Herder, F. Majer, F. Schlegel, A.W. Schlegel, (...) W. von Humboldt, and G.W.F. Hegel. Methodologically, the study attends to the intellectual contexts and prejudices that framed the early reception of the text. But it also delves deeper by investigating the way these frameworks inflected the construction of the _Bhagavadgãtà_ and its foundational concepts through the scholarly acts of excerpting, anthologization, and translation. Overall, the project contributes to the pluralization of Western philosophy and its history while simultaneously arguing for a continued critical alertness in cross-cultural comparison of philosophical and religious worldviews. (shrink)

How did the _Bhagavadgãtà_ first become an object of German philosophical and philological inquiry? How were its foundational concepts initially interpreted within German intellectual circles, and what does this episode in the history of cross-cultural encounter teach us about the status of comparative philosophy today? This book addresses these questions through a careful study of the figures who read, translated and interpreted the _Bhagavadgãtà_ around the turn of the nineteenth century in Germany: J.G. Herder, F. Majer, F. Schlegel, A.W. Schlegel, (...) W. von Humboldt, and G.W.F. Hegel. Methodologically, the study attends to the intellectual contexts and prejudices that framed the early reception of the text. But it also delves deeper by investigating the way these frameworks inflected the construction of the _Bhagavadgãtà_ and its foundational concepts through the scholarly acts of excerpting, anthologization, and translation. Overall, the project contributes to the pluralization of Western philosophy and its history while simultaneously arguing for a continued critical alertness in cross-cultural comparison of philosophical and religious worldviews. (shrink)

Human sleeping arrangements have evolved over time and differ across cultures. The majority of adults share their bed at one time or another with a partner or child, and many also sleep with pets. In fact, around half of dog and cat owners report sharing a bed or bedroom with their pet. However, interspecies co-sleeping has been trivialized in the literature relative to interpersonal or human-human co-sleeping, receiving little attention from an interdisciplinary psychological perspective. In this paper, we provide a (...) historical outline of the “civilizing process” that has led to current sociocultural conceptions of sleep as an individual, private function crucial for the functioning of society and the health of individuals. We identify similar historical processes at work in the formation of contemporary constructions of socially normative sleeping arrangements for humans and animals. Importantly, since previous examinations of co-sleeping practices have anthropocentrically framed this topic, the result is an incomplete understanding of co-sleeping practices. By using dogs as an exemplar of human-animal co-sleeping, and comparing human-canine sleeping with adult-child co-sleeping, we determine that both forms of co-sleeping share common factors for establishment and maintenance, and often result in similar benefits and drawbacks. We propose that human-animal and adult-child co-sleeping should be approached as legitimate and socially relevant forms of co-sleeping, and we recommend that co-sleeping be approached broadly as a social practice involving relations with humans and other animals. Because our proposition is speculative and derived from canine-centric data, we recommend ongoing theoretical refinement grounded in empirical research addressing co-sleeping between humans and multiple animal species. (shrink)

We describe the development, testing, and formative evaluation of nine role-play scenarios for teaching central topics in the responsible conduct of research to graduate students in science and engineering. In response to formative evaluation surveys, students reported that the role-plays were more engaging and promoted deeper understanding than a lecture or case study covering the same topic. In the future, summative evaluations will test whether students display this deeper understanding and retain the lessons of the role-play experience.

When do probability distribution functions (PDFs) about future climate misrepresent uncertainty? How can we recognise when such misrepresentation occurs and thus avoid it in reasoning about or communicating our uncertainty? And when we should not use a PDF, what should we do instead? In this paper we address these three questions. We start by providing a classification of types of uncertainty and using this classification to illustrate when PDFs misrepresent our uncertainty in a way that may adversely affect decisions. We (...) then discuss when it is reasonable and appropriate to use a PDF to reason about or communicate uncertainty about climate. We consider two perspectives on this issue. On one, which we argue is preferable, available theory and evidence in climate science basically excludes using PDFs to represent our uncertainty. On the other, PDFs can legitimately be provided when resting on appropriate expert judgement and recognition of associated risks. Once we have specified the border between appropriate and inappropriate uses of PDFs, we explore alternatives to their use. We briefly describe two formal alternatives, namely imprecise probabilities and possibilistic distribution functions, as well as informal possibilistic alternatives. We suggest that the possibilistic alternatives are preferable. -/- . (shrink)

Theories in the cognitive science of religion (CSR) are sometimes seen as debunking religious or supernatural beliefs (SBs). To date, arguments have been produced by proponents on both sides, with some claiming that debunking would result and others claiming that it would not. In this paper, I depart from the approach taken by others and offer an approach based in broadly Bayesian methods of updating subjective probability assignments, including classical Bayesian formulas as well as comparative ratios and Jeffrey conditionalization. I (...) argue that debunking may take place, but only if specified conditions are met. One way to show that debunking takes place would be to show that the probability of some CSR theory naturalistically explaining SBs diminishes when it is postulated that SBs have epistemic warrant. Another alternative would be to show that CSR theories are less likely to succeed in explaining the origin of SBs if SBs have warrant than if they lack warrant. It can also be helpful to consider the role played by uncertain and even ineffable judgments. Either way, debunking SBs does not follow simply from CSR but must be considered in light of prior epistemic commitments and the role they play in evaluating probabilities. (shrink)

Introduction: the Study of Argumentation Although our overall organization of the readings suggests one way of dividing our selected literature, ...

This volume is a serious attempt to open up the subject of European philosophy of science to real thought, and provide the structural basis for the interdisciplinary development of its specialist fields, but also to provoke reflection on the idea of ‘European philosophy of science’. This efforts should foster a contemporaneous reflection on what might be meant by philosophy of science in Europe and European philosophy of science, and how in fact awareness of it could assist philosophers interpret and motivate (...) their research through a stronger collective identity. The overarching aim is to set the background for a collaborative project organising, systematising, and ultimately forging an identity for, European philosophy of science by creating research structures and developing research networks across Europe to promote its development. (shrink)

This volume contains an array of essays that reflect, and reflect upon, the recent revival of scholarly interest in the self and consciousness. Various relevant issues are addressed in conceptually challenging ways, such as how consciousness and different forms of self-relevant experience develop in infancy and childhood and are related to the acquisition of skill; the role of the self in social development; the phenomenology of being conscious and its metapsychological implications; and the cultural foundations of conceptualizations of consciousness. Written (...) by notable scholars in several areas of psychology, philosophy, cognitive neuroscience, and anthropology, the essays are of interest to readers from a variety of disciplines concerned with central, substantive questions in contemporary social science, and the humanities. (shrink)

Doctoral programs at U.S. universities play a critical role in the development of human resources both in the United States and abroad. This volume reports the results of an extensive study of U.S. research-doctorate programs in five broad fields: physical sciences and mathematics, engineering, social and behavioral sciences, biological sciences, and the humanities. Research-Doctorate Programs in the United States documents changes that have taken place in the size, structure, and quality of doctoral education since the widely used 1982 editions. This (...) update provides selected information on nearly 4,000 doctoral programs in 41 subdisciplines at 274 doctorate-granting institutions. This volume also reports the results of the National Survey of Graduate Faculty, which polled a sample of faculty for their views on the scholarly quality of program faculty and the effectiveness of doctoral programs in preparing research scholars/scientists. This much-anticipated update of such an essential reference will be useful to education administrators, university faculty, and students seeking authoritative information on doctoral programs. (shrink)